Abstract |
A single dose of p-chloroamphetamine, 10 mg per kilogram, produced postural abnormalities, tremor, myoclonus, and autonomic signs in rats 5 minutes after intraperitoneal injection. This syndrome lasted 60 to 90 minutes, and its intensity was directly proportional to the amount of p-chloroamphetamine given over a 2 to 10 mg per kilogram range. Whole-brain levels of serotonin and 5-hydroxyindoleacetic acid were not altered during this interval, although both were reduced significantly 1 day later. Pretreatment with drugs that interfere with the uptake of p-chloroamphetamine into terminals of serotonergic neurons ( fluoxetine), depress brain serotonin levels ( p-chlorophenylalanine), or block serotonin receptors ( methiothepin or methergoline) suppressed this syndrome, whereas drugs that antagonize the effects of dopamine, norepinephrine, and acetylcholine did not. These observations implicate serotonergic mechanisms and provide behavioral evidence of p-chloroamphetamine's immediate actions on serotonergic neurons in the central nervous system.
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Authors | J H Growdon |
Journal | Neurology
(Neurology)
Vol. 27
Issue 11
Pg. 1074-7
(Nov 1977)
ISSN: 0028-3878 [Print] United States |
PMID | 563003
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Amphetamines
- Serotonin Antagonists
- Serotonin
- Hydroxyindoleacetic Acid
- p-Chloroamphetamine
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Topics |
- Amphetamines
(toxicity)
- Animals
- Dose-Response Relationship, Drug
- Hydroxyindoleacetic Acid
(metabolism)
- Male
- Motor Activity
(drug effects)
- Myoclonus
(chemically induced)
- Posture
- Rats
- Serotonin
(metabolism)
- Serotonin Antagonists
- Tremor
(chemically induced)
- p-Chloroamphetamine
(toxicity)
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