[E-vitamin activity of vitamin E derivatives with experimental encephalomalacia in chicks].

Abstract

When adding pharmacopoeian alpha-tocopherylacetate, short-chain alpha-tocopherylacetate, alpha-tocopherylquinine, short-chain alpha-tocopherylquinone and alpha-tocopheronolactone to E-avitaminotic rations pharmacopoeian alpha-tocopherylacetate and alpha-tocopheronolactone manifest the highest E-vitamin activity in preventing encephalomalacia in chickens. The action of alpha-tocopheronolactone is not directly associated with changes in the content of vitamin E and ubiquinone in the brain and liver tissues. All the studied derivatives are effective in increasing resistance of erythrocytes to osmotic hemolysis. The data obtained evidence for a nonspecific function of vitamin E in preventing alimentary encephalomalacia in chickens as well as for the absence of disturbances in ubiquinone metabolism under conditions of the E-hypovitaminosis experimental model.

• Authors: V N Kovalenko, G V Donchenko, V P Makovetskiĭ, A A Svishchuk
• Journal: Ukrainskii biokhimicheskii zhurnal (1978) (Ukr Biokhim Zh (1978)) 1979 Nov-Dec Vol. 51 Issue 6 Pg. 665-8 ISSN: 0201-8470 [Print] Ukraine
• Vernacular Title: E-vitaminnaia aktivnost' proizvodnykh vitamina E pri eksperimental'noĭ entsefalomaliatsii u tsypliat.
• PMID: 543031 (Publication Type: English Abstract, Journal Article)

Chemical References

• Vitamin E

Topics

• Animals
• Chickens
• Disease Models, Animal
• Encephalomalacia (drug therapy)
• Structure-Activity Relationship
• Vitamin E (analogs & derivatives, therapeutic use)