Chylomicrons and the formation of foam cells in type I hyperlipoproteinemia. A morphologic study.

Abstract

Light and electron microscopic study of aspirated bone marrow of a patient with type I hyperlipoproteinemia disclosed large, birefringent foam cells which develop from phagocytosis of chylomicrons by histiocytes. Chylomicrons are taken up, singly and in aggregates, by infoldings of the plasma membranes of histiocytes; these infoldings become phagocytic vacuoles within the cytoplasm. As chylomicrons are metabolized, the foam cells decrease in size, lose birefringence and develop autofluorescent, electron-dense deposits of ceroid.

• Authors: V J Ferrans, W C Roberts, R I Levy, D S Fredrickson
• Journal: The American journal of pathology (Am J Pathol) Vol. 70 Issue 2 Pg. 253-72 (Feb 1973) ISSN: 0002-9440 [Print] United States
• PMID: 4566992 (Publication Type: Journal Article)

Chemical References

• Chylomicrons
• Lipoproteins
• Pigments, Biological
• Triglycerides
• Cholesterol

Topics

• Adult
• Birefringence
• Blood Protein Disorders (pathology)
• Bone Marrow
• Bone Marrow Cells
• Cholesterol (blood)
• Chylomicrons (metabolism)
• Cytoplasmic Granules
• Golgi Apparatus
• Histiocytes
• Histocytochemistry
• Humans
• Hyperlipidemias (pathology)
• Lipoproteins (blood)
• Male
• Microscopy, Electron
• Microscopy, Phase-Contrast
• Phagocytosis
• Pigments, Biological (metabolism)
• Triglycerides (blood)