Experimental allergic neuritis induced by sensitization with galactocerebroside.

Abstract

Thirteen of 31 rabbits immunized repeatedly with bovine brain galactocerebroside developed experimental allergic neuritis, manifested by flaccid paresis and hypesthesia of four limbs, 2 to 11 months after the initial inoculation. Electrophysiological studies revealed multifocal conduction block of peripheral nerves. Perivenular demyelinative lesions associated with phagocytic mononuclear cells occurred in spinal ganglia, roots, and less frequently in distal nerves.

• Authors: T Saida, K Saida, S H Dorfman, D H Silberberg, A J Sumner, M C Manning, R P Lisak, M J Brown
• Journal: Science (New York, N.Y.) (Science) Vol. 204 Issue 4397 Pg. 1103-6 (Jun 08 1979) ISSN: 0036-8075 [Print] United States
• PMID: 451555 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Autoantibodies
• Cerebrosides
• Galactosylceramides

Topics

• Animals
• Autoantibodies (analysis)
• Autoimmune Diseases (immunology)
• Cerebrosides (immunology)
• Demyelinating Diseases (immunology, pathology)
• Galactosylceramides (immunology)
• Male
• Myelin Sheath (physiopathology)
• Neural Conduction
• Neuritis (immunology, pathology, physiopathology)
• Rabbits