Abstract |
The lipid changes in the inheritable foam cell reticulosis of mice discovered by Lyons, Hulse, and Rowe have been reexamined. The major abnormality in thymuses from homozygous-abnormal animals has been identified as an increase in the concentration (per milligram of protein) of sphingomyelin and cholesterol. This increase is associated with normal sphingomyelin-cleaving activity. The lipid compositions of the liver and spleen in the homozygous-abnormal animal and of the thymus in the heterozygous-abnormal mouse are normal. The disorder appears to be chemically analogous to those forms of human sphingomyelin lipidosis ( Niemann-Pick disease) that are not accompanied by a decrease in tissue sphingomyelinase.
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Authors | D S Fredrickson, H R Sloan, C T Hansen |
Journal | Journal of lipid research
(J Lipid Res)
Vol. 10
Issue 3
Pg. 288-93
(May 1969)
ISSN: 0022-2275 [Print] United States |
PMID | 4306614
(Publication Type: Journal Article)
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Chemical References |
- Carbon Isotopes
- Lipoproteins
- Lysophosphatidylcholines
- Phosphatidylcholines
- Phosphatidylethanolamines
- Phosphatidylinositols
- Phospholipids
- Sphingomyelins
- Cholesterol
- Phospholipases
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Topics |
- Animals
- Carbon Isotopes
- Cholesterol
(metabolism)
- Chromatography, Thin Layer
- Heterozygote
- Homozygote
- Humans
- Lipoproteins
(blood)
- Liver
(enzymology, metabolism)
- Lymphatic Diseases
- Lysophosphatidylcholines
(metabolism)
- Mice
- Niemann-Pick Diseases
- Phenotype
- Phosphatidylcholines
(metabolism)
- Phosphatidylethanolamines
(metabolism)
- Phosphatidylinositols
(metabolism)
- Phospholipases
(metabolism)
- Phospholipids
(metabolism)
- Sphingomyelins
(metabolism)
- Spleen
(enzymology, metabolism)
- Thymus Gland
(enzymology, metabolism)
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