Divergent changes of serum 3,5,3'-triiodothyronine and 3,3',5'-triiodothyronine in patients with acute myocardial infarction.

Abstract

The serum levels of thyroxine (T4), 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (reverse T3, rT3), thyroxine-binding globulin and thyroid-stimulating hormone have been monitored in 13 patients with acute myocardial infarction. The major changes recorded were a transient decrease in T3 and a transient increase in rT3. They reached a nadir and a peak, respectively, within three days. A conceivable explanation for these alterations is that the monodeiodination of T4 is diverted from the activating pathway (T4 to T3) to the inactivating pathway (T4 to rT3).

• Authors: U Westgren, A Burger, K Levin, A Melander, G Nilsson, U Pettersson
• Journal: Acta medica Scandinavica (Acta Med Scand) Vol. 201 Issue 4 Pg. 269-72 ( 1977) ISSN: 0001-6101 [Print] Sweden
• PMID: 403745 (Publication Type: Journal Article)

Chemical References

• Serum Globulins
• Thyroxine-Binding Proteins
• Triiodothyronine
• Thyrotropin
• Thyroxine

Topics

• Acute Disease
• Adult
• Aged
• Female
• Humans
• Male
• Middle Aged
• Myocardial Infarction (blood)
• Serum Globulins (analysis)
• Thyrotropin (blood)
• Thyroxine (blood)
• Thyroxine-Binding Proteins (analysis)
• Triiodothyronine (blood)