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Acute erythroleukemia complicating prolonged chemotherapy for ovarian carcinoma.

Abstract
Two patients with ovarian carcinoma developed acute erythroleukemia following prolonged chemotherapy with an alkylating agent. An analysis of our patients, together with literature review of similar cases, suggests that the duration of chemotherapy may have been the most important factor in the leukemogenesis. We suggest that the duration of chemotherapy required to achieve a cure in patients with ovarian carcinoma in complete remission can be determined only by prospective controlled trials.
AuthorsJ D Khandekar, E S Kurtides, R C Stalzer
JournalArchives of internal medicine (Arch Intern Med) Vol. 137 Issue 3 Pg. 355-6 (Mar 1977) ISSN: 0003-9926 [Print] United States
PMID402895 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Chlorambucil
Topics
  • Adult
  • Aged
  • Chlorambucil (therapeutic use)
  • Female
  • Humans
  • Leukemia, Erythroblastic, Acute (chemically induced)
  • Long-Term Care
  • Ovarian Neoplasms (drug therapy)
  • Time (adverse effects)
  • Time Factors (adverse effects)

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