Abstract |
The presence of Thomsen-Friedenreich antigen (T-Ag) against bladder mucosa in bladder tumor cases and control individuals was examined by the immunoperoxidase and the immunofluorescein method using labelled lectin. T-Ag was negative in all 15 cases of non-malignant bladder epithelium, and positive on the cell surface after sialidase treatment (cryptic T-Ag positive). In the 37 out of 72 bladder tumor cases, however, cryptic T-Ag was positive, and in the remaining 35 cases T-Ag was positive or negative after sialidase treatment. Furthermore 55 cases which had received the first treatment by TUR-Bt were investigated. Thirteen of the 31 cryptic T-Ag positive cases recurred during observation after operation whereas 22 of the 24 T-Ag positive or cryptic T-Ag negative cases recurred, the rate being significantly higher for the latter. In addition, the disease-free interval was absolutely longer in the cryptic T-Ag positive cases than in T-Ag positive or cryptic T-Ag negative cases. The exploration of T-Ag in bladder cancer may be valuable for predicting the clinical course after TUR-Bt.
|
Authors | Y Oda |
Journal | Hinyokika kiyo. Acta urologica Japonica
(Hinyokika Kiyo)
Vol. 31
Issue 3
Pg. 407-18
(Mar 1985)
ISSN: 0018-1994 [Print] Japan |
PMID | 3895852
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
- Antigens, Neoplasm
- Antigens, Tumor-Associated, Carbohydrate
- Disaccharides
- Thomsen-Friedenreich antigen
|
Topics |
- Adult
- Aged
- Antigens, Neoplasm
(analysis)
- Antigens, Tumor-Associated, Carbohydrate
- Carcinoma, Transitional Cell
(diagnosis, immunology, surgery)
- Disaccharides
(analysis)
- Female
- Fluorescent Antibody Technique
- Humans
- Immunoenzyme Techniques
- Male
- Middle Aged
- Prognosis
- Urinary Bladder Neoplasms
(diagnosis, immunology, surgery)
|