Arteriographic demonstration of the release of coronary artery spasm by isosorbide dinitrate: a twenty-five-year retrospective.

Abstract

It has been 25 years since my colleagues and I were first approached to apply the then newly emerging technique of coronary arteriography to the study of the effects of the new vasodilator isosorbide dinitrate (ISDN) on coronary arteries in vivo. Through a combination of careful patient assessment and serendipity, we were able to visualize the prompt release of coronary artery spasm by ISDN. Ensuing years have seen dramatic advances both in angiographic techniques and in the knowledge of ISDN efficacy. This review will briefly summarize the early work with ISDN and detail how the improvements in cineangiography have fostered better understanding of the actions of ISDN.

• Authors: G G Gensini
• Journal: American heart journal (Am Heart J) Vol. 110 Issue 1 Pt 2 Pg. 201-3 (Jul 1985) ISSN: 0002-8703 [Print] United States
• PMID: 3893079 (Publication Type: Historical Article, Journal Article)

Chemical References

• Isosorbide Dinitrate

Topics

• Cineangiography (history)
• Coronary Vasospasm (diagnostic imaging, drug therapy, history)
• History, 20th Century
• Humans
• Isosorbide Dinitrate (therapeutic use)
• United States