Moderate weight loss and sulfonylurea treatment of non-insulin-dependent diabetes mellitus. Combined effects.

Abstract

Hypocaloric liquid formula diets were given for one month to 20 moderately obese patients with non-insulin-dependent diabetes mellitus divided into two equal groups; group 1 was treated with weight loss alone; group 2 received glipizide in addition to the hypocaloric diet. Mean weight loss was similar in the two groups (6.5 +/- 0.6 v 6.4 +/- 0.5 kg) and was associated with a statistically significant fall in mean fasting plasma glucose values from 293 +/- 15 to 232 +/- 24 mg/dL (group 1) and from 281 +/- 15 to 152 +/- 7 mg/dL (group 2). This was associated with 13% (group 1) and 36% (group 2) decrements in total postprandial glucose response. Neither fasting nor postprandial insulin levels changed significantly with weight loss, but estimates of insulin-stimulated glucose disposal demonstrated a 15% (group 1) and 42% (group 2) improvement. Finally, fasting plasma cholesterol and triglyceride concentrations fell significantly in both groups.

• Authors: G C Liu, A M Coulston, C K Lardinois, C B Hollenbeck, J G Moore, G M Reaven
• Journal: Archives of internal medicine (Arch Intern Med) Vol. 145 Issue 4 Pg. 665-9 (Apr 1985) ISSN: 0003-9926 [Print] United States
• PMID: 3885889 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Blood Glucose
• Insulin
• Lipids
• Sulfonylurea Compounds
• Glipizide

Topics

• Blood Glucose (metabolism)
• Body Weight
• Combined Modality Therapy
• Diabetes Mellitus, Type 2 (blood, complications, therapy)
• Diet, Reducing
• Fasting
• Female
• Food, Formulated
• Glipizide (therapeutic use)
• Humans
• Insulin (blood)
• Lipids (blood)
• Male
• Middle Aged
• Obesity (complications, diet therapy)
• Random Allocation
• Sulfonylurea Compounds (therapeutic use)