Effect of ascorbate on red blood cell lipid peroxidation.

Abstract

The present study investigates the effect of ascorbate on red cell lipid peroxidation. At a concentration between 0.2 mmol - 20 mmol/1 ascorbic acid reduces hydrogen peroxide-induced red blood cell lipid peroxidation resulting in a marked decrease in ethane and pentane production as well as in haemolysis. Ascorbic acid also shows an antioxidant effect on chelated iron-catalyzed hydrogen peroxide-induced peroxidation of erythrocyte membranes. At a concentration of 10 mmol/1 ascorbic acid totally inhibits oxidative break-down of polyunsaturated fatty acids by radicals originating from hydrogen peroxide. Our results indicate that ascorbate at the chosen concentration has an antioxidant effect on red blood cell lipid peroxidation.

• Authors: H Einsele, M R Clemens, H Remmer
• Journal: Free radical research communications (Free Radic Res Commun) Vol. 1 Issue 1 Pg. 63-7 ( 1985) ISSN: 8755-0199 [Print] Switzerland
• PMID: 3880016 (Publication Type: Journal Article)

Chemical References

• Fatty Acids
• Lipid Peroxides
• Pentanes
• pentane
• Hydrogen Peroxide
• Ethane
• Ascorbic Acid

Topics

• Ascorbic Acid
• Erythrocyte Membrane
• Ethane
• Fatty Acids (blood)
• Hemolysis
• Humans
• Hydrogen Peroxide
• In Vitro Techniques
• Lipid Peroxides
• Oxidation-Reduction
• Pentanes