Gut-liver interactions in the IgA system.

Abstract

Recent experimental work in rodents has demonstrated that the liver can function as an 'IgA-pump', transporting polymeric IgA from serum to bile via a secretory-component mediated uptake at the surface of the hepatic parenchymal cell. Studies are surveyed which indicate that, although this process occurs in man, it is to a strikingly lesser degree, and interruption of this pathway does not explain the high serum IgA levels often seen in chronic liver disease: the explanation for this lies in enhanced synthesis of IgA, and diminished polymeric IgA catabolism unrelated to hepatobiliary transport.

• Authors: H J Hodgson
• Journal: Scandinavian journal of gastroenterology. Supplement (Scand J Gastroenterol Suppl) Vol. 114 Pg. 39-44 ( 1985) ISSN: 0085-5928 [Print] England
• PMID: 3867129 (Publication Type: Journal Article)

Chemical References

• Immunoglobulin A
• Immunoglobulin A, Secretory
• polymeric IgA

Topics

• Animals
• Bile (immunology)
• Digestive System (immunology)
• Humans
• Hypergammaglobulinemia (immunology)
• Immunoglobulin A (metabolism)
• Immunoglobulin A, Secretory (metabolism)
• Liver (immunology)
• Liver Cirrhosis (immunology)
• Liver Diseases (immunology)