Functional and anatomic recovery in the monkey brain following excision of fetal encephalocele.

Abstract

Teratogen-induced herniation of the occipital lobes (encephalocele) in monkey fetuses was repaired by amputation and cranioplasty in utero or postnatally. The in utero-treated animals had normal vision, CT scans indicated normal brain density, and autoradiographic visualization of the striate cortex by the [14C]-2-deoxyglucose mapping revealed almost complete functional and anatomic recovery. The animals treated postnatally were blind, and exhibited significant structural deficit in the operated area.

• Authors: M Michejda, J Bacher
• Journal: Pediatric neuroscience (Pediatr Neurosci) 1985-1986 Vol. 12 Issue 2 Pg. 90-5 ISSN: 0255-7975 [Print] Switzerland
• PMID: 3837881 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Triamcinolone Acetonide

Topics

• Age Factors
• Animals
• Encephalocele (chemically induced, surgery)
• Fetus (surgery)
• Gestational Age
• Macaca mulatta
• Neuronal Plasticity
• Triamcinolone Acetonide
• Visual Cortex
• Wound Healing