[Discovery of hemoglobin J Baltimore in an episode of methemoglobinemia in an infant].

Abstract

A case of a heterozygote for Hb J Baltimore is reported in a French family. This variant hemoglobin was coincidentally discovered during an episode of methemoglobinemia in a 6-week-old baby. The father and one of the brothers were also carriers of the trait. Hematological findings for all of them were normal. As Hb J Baltimore is a frequently occurring hemoglobin variant, we discuss: its possible role in the appearance of methemoglobin, and whether this mutation in different racial groups (Caucasians of West Europe, Canadians, and American blacks) has a common origin or more probably arises from a number of independent mutations.

• Authors: R Mailfert, M L North, I Duwig, F Galacteros, D Fischer, S Mayer
• Journal: Nouvelle revue francaise d'hematologie (Nouv Rev Fr Hematol (1978)) Vol. 28 Issue 5 Pg. 315-20 ( 1986) Germany
• Vernacular Title: Découverte d'une hémoglobine J Baltimore au cours d'un épisode de méthémoglobinémie chez un nourrisson.
• PMID: 3808941 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Hemoglobins, Abnormal
• Hemoglobin J
• hemoglobin J Baltimore

Topics

• Electrophoresis
• France
• Hemoglobin J (genetics, metabolism)
• Hemoglobins, Abnormal (metabolism)
• Heterozygote
• Humans
• Hydrogen-Ion Concentration
• Infant
• Isoelectric Focusing
• Male
• Methemoglobinemia (blood, genetics)
• Oxidation-Reduction