Oxidative stress as a bridge between age and stroke: A narrative review.

Abstract

Stroke is the third most common cause of death globally and a leading cause of disability. The cellular and molecular changes following stroke and causes of neuronal death are not fully understood, and there are few effective treatments currently available. A rapid increase in the levels of reactive oxygen species (ROS) post stroke can overwhelm antioxidant defenses and trigger a series of pathophysiologic events including the inflammatory response, blood-brain barrier (BBB) disruption, apoptosis, and autophagy, ultimately leading to neuron degeneration and apoptosis. It is thought that beyond a certain age, the ROS accumulation resulting from stroke increases the risk of morbidity and mortality. In the present review, we summarize the role of oxidative stress (OS) as a link between aging and stroke pathogenesis. We also discuss how antioxidants can play a beneficial role in the prevention and treatment of stroke by eliminating harmful ROS, delaying aging, and alleviating damage to neurons.

• Authors: Shengjie Feng, Miaoxian Yang, Shengpeng Liu, Yu He, Shuixiang Deng, Ye Gong
• Journal: Journal of intensive medicine (J Intensive Med) Vol. 3 Issue 4 Pg. 313-319 (Oct 31 2023) ISSN: 2667-100X [Electronic] China
• PMID: 38028635 (Publication Type: Journal Article, Review)
• Copyright: © 2023 The Authors. Published by Elsevier B.V. on behalf of Chinese Medical Association.