Cholestasis is defined as stagnation or a marked reduction in bile secretion and flow.
Cholestatic jaundice can thus be classified as intrahepatic or extrahepatic cholestatic, depending on the level of obstruction to bile flow. It is important to recognize the complications of cholestatic in patients with chronic cholestatic
liver disease. The two most common complications of
cholestasis are
pruritus and
fatigue, with the former being the most responsive to treatment.
Cholestyramine is the first-line treatment for cholestatic
pruritus.
Rifampicin and oral
opioid antagonist naltrexone are extremely effective second-line treatments. To date, there are no specific treatments for chronic cholestatic
fatigue management.
Osteoporosis is a complication that can arise in chronic cholestatic conditions. It appears to be more prominent in individuals with cholestatic
liver disease than in patients with other chronic
liver diseases with an increased risk of fracture. The evaluation of
osteoporosis in individuals with chronic
cholestasis is similar to that in the general population.
Antiresorptive agents such as
bisphosphonates are the first-line treatment choice for
osteoporosis in patients with chronic
cholestasis. Other less common complications include
dyslipidemia, fat-soluble
vitamin deficiency, and
steatorrhea. Understanding and treating these conditions can have a significant impact on the morbidity and quality of life in this group of patients. This review aimed to provide further information about the complications of chronic
cholestasis and to highlight evidence-based test practices for the evaluation and effective management of these complications.