Abstract | Background: Methods: All randomized control trials (RCTs) reporting the use of single-dose pre-operative prophylactic antibiotics in patients undergoing acute cholecystectomy were retrieved from the search of standard medical electronic databases and analysis was conducted by using the principles of meta-analysis on the statistical software RevMan version 5. Results: Standard medical databases search produced only 3 RCTs on 781 patients undergoing acute cholecystectomy. There were 384 patients in single dose pre-operative antibiotics group whereas 397 patients were recruited in the no- antibiotics group. In the random effects model analysis, the use of single-dose preoperative prophylactic antibiotics in patients undergoing acute cholecystectomy for mild to moderate cholecystitis failed to demonstrate any extra advantage of reducing the risk of [risk ratio (RR) =0.69; 95% confidence interval (CI): 0.46-1.03; Z=1.80; P=0.07] infective complications. There was no heterogeneity [Tau2 =0; Chi2 =1.74, df =2 (P=0.42; I2=0%)] among included studies. Conclusions: A preoperative single dose of prophylactic antibiotics in patients undergoing acute LC for mild to moderate acute cholecystitis does not offer extra benefits to reduce infective complications.
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Authors | Anurag Singh, Mandeep Kaur, Christie Swaminathan, Atreya Subramanian, Krishna K Singh, Muhammad S Sajid |
Journal | Translational gastroenterology and hepatology
(Transl Gastroenterol Hepatol)
Vol. 8
Pg. 37
( 2023)
ISSN: 2415-1289 [Electronic] China |
PMID | 38021359
(Publication Type: Journal Article)
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Copyright | 2023 Translational Gastroenterology and Hepatology. All rights reserved. |