Oral Chronic Graft-versus-Host Disease in Post-Hematopoietic Stem Cell Transplant Patients Following SARS-CoV-2 Vaccination: Case Reports.

Abstract

Patients receiving allogeneic hematopoietic stem cell transplant may experience graft-versus-host disease (GVHD) in which donor immune cells cause an immune reaction in host tissues. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines are highly effective in prevention of severe coronavirus-2019 (COVID-19) disease, but the vaccine can result in immune activation and GVHD. Herein, we report 4 cases of oral manifestations that may have been stimulated by COVID-19 or vaccination with Pfizer or Moderna vaccines. We believe this study is the first to report oral changes driven by an inflammatory/immune mechanism leading to oral symptomatic cGVHD. The clinical impact of this study is early recognition and appropriate management of oral symptomatic cGVHD following COVID-19 disease or SARS-CoV-2 vaccination.

• Authors: Joel B Epstein, Raymond S Hernandez, Ryotaro Nakamura, Susan E Yost, Haris Ali
• Journal: Case reports in oncology (Case Rep Oncol) 2023 Jan-Dec Vol. 16 Issue 1 Pg. 1287-1292 ISSN: 1662-6575 [Print] Switzerland
• PMID: 37928865 (Publication Type: Case Reports)
• Copyright: © 2023 The Author(s). Published by S. Karger AG, Basel.