13C and 15N resonance assignments of alpha synuclein fibrils amplified from Lewy Body Dementia tissue.

Abstract

Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of 13C, 15N assignments that are unique to fibrils obtained by amplification from postmortem brain tissue of a patient diagnosed with Lewy Body Dementia.

• Authors: Alexander M Barclay, Dhruva D Dhavale, Collin G Borcik, Moses H Milchberg, Paul T Kotzbauer, Chad M Rienstra
• Journal: Biomolecular NMR assignments (Biomol NMR Assign) Vol. 17 Issue 2 Pg. 281-286 (12 2023) ISSN: 1874-270X [Electronic] Netherlands
• PMID: 37919529 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
• Copyright: © 2023. The Author(s), under exclusive licence to Springer Nature B.V.

Chemical References

• alpha-Synuclein

Topics

• Humans
• alpha-Synuclein (chemistry)
• Lewy Body Disease (pathology)
• Nuclear Magnetic Resonance, Biomolecular
• Parkinson Disease (metabolism, pathology)
• Multiple System Atrophy (metabolism, pathology)