Abstract | Introduction: Case report: A 30-year-old Qatari man presented with a meningococcal infection, which was verified by a blood culture. He experienced two episodes of meningitis caused by an undetermined organism. His blood tests revealed low levels of CH50 and C7. His C7 gene testing revealed a homozygous mutation in exon 10 (c.1135G>C p.Gly379Arg), a mutation that has not been previously documented in Qatar. However, it has been observed in 1% of Moroccan-origin Israeli Jews who also exhibit C7 deficiency. Regular prophylactic quadrivalent vaccinations against types A, C, Y, and W-135 with azithromycin tabs were administered. Over the last 10 years of follow-up, he remained in good health, with no further meningitis episodes. Conclusion: To our knowledge, this is the first confirmed case of C7 deficiency reported in the Arabian Gulf countries. Such rare diseases should be a public health priority. Awareness among medical practitioners and the community should help with early detection of C7 deficiency and the prevention of its consequences.
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Authors | Sally Mahgoub Khalil, Sami Aqel, Dalal Sideeg Mudawi, Hassan Mobayed, Maryam Ali Al-Nesf |
Journal | Frontiers in immunology
(Front Immunol)
Vol. 14
Pg. 1253301
( 2023)
ISSN: 1664-3224 [Electronic] Switzerland |
PMID | 37885879
(Publication Type: Case Reports)
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Copyright | Copyright © 2023 Khalil, Aqel, Mudawi, Mobayed and Al-Nesf. |
Chemical References |
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Topics |
- Male
- Humans
- Adult
- Complement C7
(genetics)
- Qatar
- Follow-Up Studies
- Neisseria meningitidis
- Meningitis
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