Intralesional Measles, Mumps and Rubella Vaccine versus Formic Acid Puncture in the Treatment of Common Warts: A Prospective Randomised Study.

Abstract

Context:

Many therapeutic modalities have been reported for the treatment of warts: a common bothersome condition; however, no single treatment is completely effective.

Aims:

This study aimed to evaluate the efficacy and safety of intralesional injection of measles, mumps and rubella (MMR) vaccine and to compare its efficacy with 85% formic acid puncture for common warts.

Settings and Design:

This was a prospective comparative study.

Methods and Material:

A total of 60 patients, divided into two groups, were included in the study. Group A received an intralesional MMR vaccine of 0.3 ml per lesion, and group B received 85% formic acid puncture into each lesion with a maximum of 10 warts treated in each case. Five sessions were conducted every 2 weeks in each case with a follow-up period of 3 months to check for recurrence.

Statistical Analysis Used:

The Chi-square test, Fisher's test and t-test were used for statistical analysis. A P-value <0.05 was considered statistically significant.

Results:

In group A, the complete response was observed in 62.5%, partial response in 8% and no response in 4.1% of patients. In group B, the complete response was observed in 31.8%, partial response in 63.6% and no response in 4.5% of patients. The difference in cure rates was found to be statistically significant with a P value of 0.031. No recurrence was observed in both groups in the follow-up period.

Conclusions:

Immunotherapy by intralesional MMR vaccine is a simple, well-tolerated, effective and cost-benefit modality for the treatment of warts and showed a statistically significant cure rate than formic acid therapy.

• Authors: Myfanwy J D'Souza, Ganesh K Hundi, Sukumar Dandekeri, Jyothi Jayaraman
• Journal: Indian journal of dermatology (Indian J Dermatol) 2023 Jul-Aug Vol. 68 Issue 4 Pg. 486 ISSN: 1998-3611 [Electronic] India
• PMID: 37822387 (Publication Type: Journal Article)
• Copyright: Copyright: © 2023 Indian Journal of Dermatology.