What is the most effective and safest Non-steroidal anti-inflammatory drug for treating osteoarthritis in patients with comorbidities?

Abstract

INTRODUCTION:

Understanding what the most effective and safe non-steroidal anti-inflammatory drug (NSAID) is for managing osteoarthritis (OA) is complicated. OA is prevalent worldwide and people living with OA commonly have multiple comorbidities. The efficacy and safety of NSAIDs in a patient are influenced by their intrinsic and extrinsic factors. Current guidelines recommend the lowest dose for the shortest duration, monitoring patients for risk factors and comorbidities but generally do not specify, which NSAID is most suitable for a patient with specific comorbidities.

AREAS COVERED:

This paper looks at the mechanism of action of all NSAIDs and reviews the current literature concerning their safety in patients with and without comorbidities. Relevant publications were identified by searching PubMed and Cochrane Library using key terms. The search was conducted from inception to 18 July 2023 and included results published before 18 July 2023. The search results and their references were then manually reviewed.

EXPERT OPINION:

In the paper, we determine whether the current practice of 'lowest dose for shortest duration' is in fact the best approach for prescribing NSAIDs and identify which NSAIDs are most suitable given a patient's risk factors and comorbidities. Our aim is to help guide health professionals in recommending the most suitable NSAID for each patient.

• Authors: Quentin E Geczy, Aricia J Thirumaran, Peter R Carroll, Andrew J McLachlan, David J Hunter
• Journal: Expert opinion on drug metabolism & toxicology (Expert Opin Drug Metab Toxicol) 2023 Jul-Dec Vol. 19 Issue 10 Pg. 681-695 ISSN: 1744-7607 [Electronic] England
• PMID: 37817419 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal

Topics

• Humans
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Osteoarthritis (drug therapy, chemically induced)
• Comorbidity
• Risk Factors