Abstract | BACKGROUND: METHODS: N = 88 ALS patients without frontotemporal dementia were assessed for FI-Katz's Basic ADL Scale (BADL) and Lawton-Brody's Instrumental ADL Scale (IADL)-, cognition-Edinburgh Cognitive and Behavioural ALS Screen (ECAS)-and behaviour-Beaumont Behavioural Inventory and Dimensional Apathy Scale. The association between cognitive and behavioural measures and BADL/IADL scores was assessed by covarying for demographics, anxiety and depression levels, disease duration and motor confounders-i.e. ALS Functional Rating Scale-Revised (ALSFRS-R) scores, progression rate and both King's and Milano-Torino stages. RESULTS: Higher scores on the ECAS-Language were associated with higher IADL scores (p = 0.005), whilst higher apathetic features-as measured by the Dimensional Apathy Scale ( DAS)-were inversely related to the BADL (p = 0.003). Whilst IADL scores were related to all ECAS-Language tasks, the DAS-Initiation was the only subscale associated with BADL scores. Patients with abnormal ECAS-Language (p = 0.023) and DAS (p = 0.008) scores were more functionally dependent than those without. DISCUSSION: Among non-motor features, language changes and apathetic features detrimentally affect FI in non-demented ALS patients.
|
Authors | Edoardo Nicolò Aiello, Federica Solca, Silvia Torre, Francesco Gentile, Francesco Scheveger, Marco Olivero, Eleonora Colombo, Alessio Maranzano, Martina Manzoni, Claudia Morelli, Alberto Doretti, Federico Verde, Vincenzo Silani, Nicola Ticozzi, Barbara Poletti |
Journal | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
(Neurol Sci)
(Sep 29 2023)
ISSN: 1590-3478 [Electronic] Italy |
PMID | 37773576
(Publication Type: Journal Article)
|
Copyright | © 2023. The Author(s). |