Abstract | OBJECTIVE: METHODS: RESULTS: SAP was confirmed by significant histopathological damage to the pancreas. ZER (10, 20 and 40 mg/kg) was found to alleviate pancreatitis and decrease ascites volume, lung W/D ratio, pancreatic pathology score, oxidative stress and inflammatory damage. High concentrations (20 and 40 mg/kg) of ZER were shown to increase levels of hepatorenal toxicity. In contrast, 10 mg/kg ZER was found to attenuate liver enzyme levels, reduce pathological damage to the liver, and protect against extrapancreatic organ damage to the liver in SAP-induced rats. Moreover, ZER showed no significant side effects in normal rats. Finally, we demonstrated that ZER mediated its anti-inflammatory effects on SAP through the ROS/NF-κB signaling pathway. CONCLUSION: ZER alleviated SAP-induced oxidative stress and inflammatory injury via the ROS/NF-κB pathway, and had a protective effect on lung injury and liver damage.
|
Authors | Fengmei Zhang, Dongjia Xu |
Journal | BMC gastroenterology
(BMC Gastroenterol)
Vol. 23
Issue 1
Pg. 333
(Sep 27 2023)
ISSN: 1471-230X [Electronic] England |
PMID | 37759163
(Publication Type: Journal Article)
|
Copyright | © 2023. BioMed Central Ltd., part of Springer Nature. |
Chemical References |
- NF-kappa B
- zerumbone
- Reactive Oxygen Species
|
Topics |
- Animals
- Rats
- NF-kappa B
- Reactive Oxygen Species
- Pancreatitis
(chemically induced, drug therapy)
- Acute Disease
|