Glucose-6-phosphate dehydrogenase deficiency accelerates arterial aging in diabetes.

Abstract

AIMS:

High glucose levels and Glucose-6-Phosphate Dehydrogenase deficiency (G6PDd) have both tissue inflammatory effects. Here we determined whether G6PDd accelerates arterial aging (information linked stiffening) in diabetes.

METHODS:

Plasma glucose, interleukin 6 (IL6), and arterial stiffness (indexed as carotid-femoral Pulse Wave Velocity, PWV) and red blood cell G6PD activity were assessed in a large (4448) Sardinian population.

RESULTS:

Although high plasma glucose in diabetics, did not differ by G6DP status (178.2 ± 55.1 vs 169.0 ± 50.1 mg/dl) in G6DPd versus non-G6PDd subjects, respectively, IL6, and PWV (adjusted for age and glucose) were significantly increased in G6PDd vs non-G6PDd subjects (PWV, 8.0 ± 0.4 vs 7.2 ± 0.2 m/sec) and (IL6, 6.9 ± 5.0 vs 4.2 ± 3.0 pg/ml). In non-diabetics, neither fasting plasma glucose, nor IL6, nor PWV were impacted by G6PDd.

CONCLUSION:

G6PDd in diabetics is associated with increased inflammatory markers and accelerated arterial aging.

• Authors: Angelo Scuteri, Christopher H Morrell, Majd AlGhatrif, Marco Orru, Edoardo Fiorillo, Michele Marongiu, David Schlessinger, Francesco Cucca, Edward G Lakatta
• Journal: Acta diabetologica (Acta Diabetol) (Sep 23 2023) ISSN: 1432-5233 [Electronic] Germany
• PMID: 37741911 (Publication Type: Journal Article)
• Copyright: © 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023.