Abstract |
The abnormal concentration of anthrax spore biomarker 2,6-pyridinedicarboxylic acid (2,6-DPA) will seriously affect public health. Therefore, a sensitive and rapid assay for 2,6-DPA monitoring is of vital importance. In this work, novel nano-sized amorphous Eu-NH2BDC (amEu-NH2BDC) and amorphous Tb-NH2BDC (amTb-NH2BDC) metal organic frameworks are prepared by adjusting the ratio of metal and ligand, respectively. Both of them exhibit highly sensitive and selective ratiometric fluorescence detection for 2,6-DPA with wider linear range and lower detection limit in aqueous solutions and human serum. Attributed to the coordination effect of 2,6-DPA in triggering the characteristic fluorescence emissions of Eu3+or Tb3+ by replacing coordinated solvent molecules, as evidenced by ultraviolet-visible spectroscopy, the fluorescence lifetimes analysis, thermal gravimetric analysis, Fourier-transform infrared spectroscopy, density functional theory (DFT) simulations and X-ray photoelectron spectroscopy. In addition, the amEu-NH2BDC or amTb-NH2BDC loaded paper-based microsensors are constructed for real-time and sensitive detection of 2,6-DPA and coupled with a smartphone-assisted visual portable device.
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Authors | Jiaqi Dang, Min Li, Wenhui Fang, Ying Wu, Shixian Xin, Yutao Cao, Hong Zhao |
Journal | Talanta
(Talanta)
Vol. 267
Pg. 125164
(Jan 15 2024)
ISSN: 1873-3573 [Electronic] Netherlands |
PMID | 37734290
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 Elsevier B.V. All rights reserved. |
Chemical References |
- Metal-Organic Frameworks
- Biomarkers
- Fluorescent Dyes
- Picolinic Acids
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Topics |
- Humans
- Bacillus anthracis
- Smartphone
- Anthrax
(diagnosis)
- Metal-Organic Frameworks
- Spectrometry, Fluorescence
(methods)
- Biomarkers
(analysis)
- Fluorescent Dyes
(chemistry)
- Picolinic Acids
(analysis)
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