Stimulation of Erythrocyte Soluble Guanylyl Cyclase Induces cGMP Export and Cardioprotection in Type 2 Diabetes.

Abstract

Reduced nitric oxide (NO) bioactivity in red blood cells (RBCs) is critical for augmented myocardial ischemia-reperfusion injury in type 2 diabetes. This study identified the nature of "NO bioactivity" by stimulating the intracellular NO receptor soluble guanylyl cyclase (sGC) in RBCs. sGC stimulation in RBCs from patients with type 2 diabetes increased export of cyclic guanosine monophosphate from RBCs and activated cardiac protein kinase G, thereby attenuating ischemia-reperfusion injury. These results provide novel insight into RBC signaling by identifying cyclic guanosine monophosphate from RBC as a mediator of protection against cardiac ischemia-reperfusion injury induced by sGC stimulation in RBCs.

• Authors: Tong Jiao, Aida Collado, Ali Mahdi, John Tengbom, Yahor Tratsiakovich, G Todd Milne, Michael Alvarsson, Jon O Lundberg, Zhichao Zhou, Jiangning Yang, John Pernow
• Journal: JACC. Basic to translational science (JACC Basic Transl Sci) Vol. 8 Issue 8 Pg. 907-918 (Aug 2023) ISSN: 2452-302X [Electronic] United States
• PMID: 37719424 (Publication Type: Journal Article)
• Copyright: © 2023 The Authors.