Normal thermostability of hypoxanthine guanine phosphoribosyltransferase in erythrocytes from Werner's syndrome patients.

Abstract

The thermostability of erythrocyte hypoxanthine guanine phosphoribosyltransferase of 2 Werner's syndrome patients was compared with that of normal subjects of different ages. No significant difference was observed regarding the thermal stability of the enzyme among normal subjects and Werner's syndrome patients. The activities of other erythrocyte enzymes, phosphoribosylpyrophosphate synthetase, adenine phosphoribosyltransferase, adenosine deaminase and purine nucleoside phosphorylase, were similar between Werner's syndrome and normal subjects.

• Authors: F Takeuchi, M Goto, T Miyamoto
• Journal: Gerontology (Gerontology) Vol. 32 Issue 4 Pg. 196-201 ( 1986) ISSN: 0304-324X [Print] Switzerland
• PMID: 3770488 (Publication Type: Journal Article)

Chemical References

• Purines
• Hypoxanthine Phosphoribosyltransferase

Topics

• Adult
• Aged
• Aged, 80 and over
• Drug Stability
• Erythrocytes (enzymology)
• Hot Temperature
• Humans
• Hypoxanthine Phosphoribosyltransferase (metabolism)
• Middle Aged
• Purines (metabolism)
• Werner Syndrome (enzymology)