Serial 68Ga-FAPI PET/CT After Treatment of Immunoglobulin G4-Related Pancreatitis and Retroperitoneal Fibrosis.

Abstract

ABSTRACT:

Immunoglobulin G4 (IgG4)-related disease is a fibroinflammatory condition involving diverse organs. We report a case of IgG4-related pancreatitis and retroperitoneal fibrosis with serial 68Ga-FAPI PET/CT scans after treatment. A 64-year-old man presented with left flank and epigastric pain. Laboratory, abdominal CT, and 68Ga-FAPI PET/CT findings were suggestive of IgG4-related pancreatitis and retroperitoneal fibrosis. Histology of the pancreas confirmed IgG4-related pancreatitis. The follow-up PET/CT scans after treatment with steroid therapy showed regression of 68Ga-FAPI uptake in the pancreas and periureteral soft tissue. The changes on 68Ga-FAPI PET/CT scans were much more prominent compared with the CT scans.

• Authors: Eunae Cho, Chang Hwan Park, Jahae Kim, Kangbin Kim, Sung Sun Kim
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 48 Issue 10 Pg. 883-887 (Oct 01 2023) ISSN: 1536-0229 [Electronic] United States
• PMID: 37682605 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• 68Ga-FAPI
• Immunoglobulin G

Topics

• Male
• Humans
• Middle Aged
• Retroperitoneal Fibrosis (diagnostic imaging, drug therapy)
• Positron Emission Tomography Computed Tomography
• Autoimmune Pancreatitis
• Pancreatitis (diagnostic imaging, drug therapy)
• Immunoglobulin G
• Immunoglobulin G4-Related Disease (diagnostic imaging, drug therapy)