Abstract | OBJECTIVE: METHODS: Altitude-induced fatigue model rats were established in a large hypobaric chamber. Swimming time, energy storage substances, metabolic enzymes, and metabolites were used to evaluate the anti- fatigue activities and mechanism of three PhGs ( verbascoside, echinacoside, and crenatoside) (150 mg/kg, intragastric administration) in the hypoxic environment. RESULTS: The three PhGs, especially verbascoside, could prolong the swimming time of rats, ameliorate the edema and inflammatory infiltration of liver and skeletal muscle, increase the level of energy storage substances, reduce the decomposition of proteins, and exhibit positive effects on the metabolism-related enzyme activity and metabolites. CONCLUSIONS: The PhGs, especially verbascoside, are very potential with anti- fatigue activity in hypoxia. The mechanism may be explained with regulation of energy metabolism and reduction of oxidative stress.
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Authors | Guo Ziliang, Qian Qingyuan, L I Xiaolin, Zhu Yuting, Ren Jun, L I Maoxing |
Journal | Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
(J Tradit Chin Med)
Vol. 43
Issue 5
Pg. 934-943
(10 2023)
ISSN: 2589-451X [Electronic] China |
PMID | 37679981
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- acteoside
- crenatoside
- echinacoside
- Glycosides
- Phenols
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Topics |
- Animals
- Rats
- Altitude
- Glycosides
(therapeutic use)
- Hypoxia
(drug therapy)
- Phenols
(therapeutic use)
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