Abstract | RATIONALE: PATIENT CONCERNS: DIAGNOSES: On physical examination, the patient's right eye could not fully move to the right side and horizontal nystagmus was found. Coordination was also impaired in the upper and lower extremities with dysmetria and dysdiadochokinesia. The electromyography and cerebrospinal fluid examination results were normal. The serum anti-GQlb antibody test results were negative. However, serum anti-GD1b IgM and anti-GM1 IgM antibodies were positive. Meanwhile, the anti- thyroid peroxidase antibody was >600.00 IU/mL (0.00-34.00), and the anti-SS-A/Ro52 antibody was positive. He was diagnosed with MFS. INTERVENTIONS: The patient received IVIg treatment for 5 days (0.4 g/kg/day) from day 2 to day 6 of hospitalization. On the 7th day of admission, the patient was administered intravenous methylprednisolone (500 mg/day), which was gradually reduced. OUTCOMES: LESSONS: We report a case of MFS with positive anti-GD1b and anti-GM1 antibodies combined with multiple autoimmune antibodies. Positive ganglioside antibodies may be used as supporting evidence for the diagnosis; however, the diagnosis of MFS is more dependent on clinical symptoms.
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Authors | Limei Zhang, Linqing Ma, Lihua Zhou, Lu Sun, Chunru Han, Qi Fang |
Journal | Medicine
(Medicine (Baltimore))
Vol. 102
Issue 34
Pg. e34969
(Aug 25 2023)
ISSN: 1536-5964 [Electronic] United States |
PMID | 37653808
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. |
Chemical References |
- Gangliosides
- Immunoglobulin M
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Topics |
- Male
- Humans
- Middle Aged
- Miller Fisher Syndrome
(diagnosis, drug therapy)
- Eye
- Administration, Intravenous
- Ambulatory Care Facilities
- Gangliosides
- Immunoglobulin M
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