Abstract | Objective: Methods: The experimental group underwent local anticoagulation with citrate, whereas the control group received systemic anticoagulation with heparin. Relevant data from randomized controlled trials (RCTs) meeting the inclusion criteria were independently extracted through computer searches of the China Journal Full Text Database (CNKI), Wanfang, and Vipul databases. Additionally, references to included literature were searched to expand the dataset. Extracted RCTs that met inclusion criteria underwent independent quality evaluation and cross-checking using the Cochrane systematic review method. Subsequently, a meta-analysis was conducted using Stata 12.0 software. Results: The analysis included seven studies involving a total of 652 patients. After treatment, renal function improvement was significantly more significant in the citrate group, while creatinine and urea nitrogen levels showed a more significant decrease in the heparin group, with statistically significant differences (WMD = -51.30, 95% CI = -68.54 ~ -34.06, P = .000 and WMD = 3.68, 95% CI = -4.52 ~ -2.85, P = .000). The filter lifespan in the citrate group was significantly longer than in the heparin group, with a statistically significant difference (WMD = 6.93, 95% CI = 6.30 ~ 7.55, P = .000). Adverse bleeding reactions were significantly less common in the citrate group compared to the heparin group, with a statistically significant difference (RR = 0.14, 95% CI = 0.06 ~ 0.32, P = .000). Conclusions:
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Authors | Sen Lin, MeiYing Xiao, QingZong Cai, YuXia Lin, JinYin Yao, XiaoDong Sun, JinHua Huang |
Journal | Alternative therapies in health and medicine
(Altern Ther Health Med)
Vol. 29
Issue 8
Pg. 421-425
(Nov 2023)
ISSN: 1078-6791 [Print] United States |
PMID | 37652410
(Publication Type: Systematic Review, Meta-Analysis, Journal Article)
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Chemical References |
- Heparin
- Citric Acid
- Anticoagulants
- Citrates
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Topics |
- Humans
- Heparin
(adverse effects)
- Citric Acid
(adverse effects)
- Continuous Renal Replacement Therapy
- Anticoagulants
(adverse effects)
- Citrates
- Acute Kidney Injury
(drug therapy)
- Sepsis
(drug therapy)
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