PermaNet Dual, a new deltamethrin-chlorfenapyr mixture net, shows improved efficacy against pyrethroid-resistant Anopheles gambiae sensu lato in southern Benin.

Abstract

Pyrethroid-chlorfenapyr nets have demonstrated improved entomological and epidemiological impact in trials across Africa. This is driving increased demand for this novel net class in malaria-endemic countries. PermaNet Dual is a new deltamethrin-chlorfenapyr net developed by Vestergaard Sàrl to provide more options to malaria control programmes. We performed an experimental hut trial to evaluate the efficacy of PermaNet Dual against wild, free-flying pyrethroid-resistant Anopheles gambiae sensu lato in Covè, Benin. PermaNet Dual induced superior levels of mosquito mortality compared to a pyrethroid-only net and a pyrethroid-piperonyl butoxide net both when unwashed (77% with PermaNet Dual vs. 23% with PermaNet 2.0 and 56% with PermaNet 3.0, p < 0.001) and after 20 standardised washes (75% with PermaNet Dual vs. 14% with PermaNet 2.0 and 30% with PermaNet 3.0, p < 0.001). Using a provisional non-inferiority margin defined by the World Health Organisation, PermaNet Dual was also non-inferior to a pyrethroid-chlorfenapyr net that has demonstrated improved public health value (Interceptor G2), for vector mortality (79% vs. 76%, OR = 0.878, 95% CIs 0.719-1.073) but not for blood-feeding protection (35% vs. 26%, OR = 1.424, 95% CIs 1.177-1.723). PermaNet Dual presents an additional option of this highly effective net class for improved control of malaria transmitted by pyrethroid-resistant mosquitoes.

• Authors: Thomas Syme, Boris N'dombidjé, Martial Gbegbo, Damien Todjinou, Victoria Ariori, Patricia De Vos, Olivier Pigeon, Corine Ngufor
• Journal: Scientific reports (Sci Rep) Vol. 13 Issue 1 Pg. 12232 (07 28 2023) ISSN: 2045-2322 [Electronic] England
• PMID: 37507423 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2023. The Author(s).

Chemical References

• decamethrin
• chlorfenapyr
• Insecticides
• Pyrethrins

Topics

• Animals
• Humans
• Anopheles
• Insecticides (pharmacology)
• Benin (epidemiology)
• Mosquito Control
• Insecticide-Treated Bednets
• Mosquito Vectors
• Pyrethrins (pharmacology)
• Malaria (prevention & control)
• Insecticide Resistance