Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability.

Abstract

Transcription elongation requires elaborate coordination between the transcriptional machinery and chromatin regulatory factors to successfully produce RNA while preserving the epigenetic landscape. Recent structural and genomic studies have highlighted that suppressor of Ty 6 (Spt6), a conserved histone chaperone and transcription elongation factor, sits at the crux of the transcription elongation process. Other recent studies have revealed that Spt6 also promotes DNA replication and genome integrity. Here, we review recent studies of Spt6 that have provided new insights into the mechanisms by which Spt6 controls transcription and have revealed the breadth of Spt6 functions in eukaryotic cells.

• Authors: Catherine L W Miller, James L Warner, Fred Winston
• Journal: Trends in genetics : TIG (Trends Genet) Vol. 39 Issue 11 Pg. 858-872 (11 2023) ISSN: 0168-9525 [Print] England
• PMID: 37481442 (Publication Type: Journal Article, Review, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2023 Elsevier Ltd. All rights reserved.

Chemical References

• Histone Chaperones
• Histones
• Saccharomyces cerevisiae Proteins
• Transcription Factors
• Transcriptional Elongation Factors
• SUPT6H protein, human

Topics

• Humans
• DNA Replication (genetics)
• Genomic Instability (genetics)
• Histone Chaperones (genetics, chemistry, metabolism)
• Histones (genetics, metabolism)
• Saccharomyces cerevisiae (genetics)
• Saccharomyces cerevisiae Proteins (chemistry, genetics, metabolism)
• Transcription Factors (genetics)
• Transcription, Genetic
• Transcriptional Elongation Factors (genetics, chemistry, metabolism)
• Animals