Abstract | BACKGROUND: Odontogenic keratocysts constitute 10%-20% of odontogenic cysts and exhibit a distinctive corrugated parakeratinized lining epithelium. Considering that cornified envelope formation is an important phenomenon during keratinocyte differentiation, this study aimed to clarify the characteristics of cornified envelope formation in odontogenic keratocysts. METHODS: We investigated the cellular distribution of cornified envelope-related proteins ( transglutaminases and their substrates), as well as the upstream regulatory protein c-Fos, by immunohistochemical analysis of the lining epithelium of 20 odontogenic keratocysts. We examined the corresponding mRNA levels by quantitative polymerase chain reaction. Ten dentigerous cysts served as control non-keratinized cysts. RESULTS: CONCLUSION: Surprisingly, the overall appearance of cornified envelope-related proteins of odontogenic keratocysts was consistent with the characteristics of non-keratinized oral mucosa identified in previous studies. These findings indicate that the contribution of cornified envelope-related molecules in odontogenic keratocysts is similar to that in non-keratinized oral epithelium, rather than keratinized oral epithelium, suggesting that odontogenic keratocysts are not genuine keratinized cysts. The upregulation of cornified envelope-related genes in odontogenic epithelium could be an important pathognomonic event during odontogenic keratocyst development.
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Authors | Rita R Roy, Takanaga Ochiai, Katsumitsu Shimada, Hiromasa Hasegawa |
Journal | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
(J Oral Pathol Med)
Vol. 52
Issue 8
Pg. 758-765
(Sep 2023)
ISSN: 1600-0714 [Electronic] Denmark |
PMID | 37438940
(Publication Type: Journal Article)
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Copyright | © 2023 The Authors. Journal of Oral Pathology & Medicine published by John Wiley & Sons Ltd. |
Chemical References |
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Topics |
- Humans
- Dentigerous Cyst
(pathology)
- Odontogenic Cysts
(genetics, pathology)
- Epithelium
(pathology)
- Transglutaminases
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