Abstract | PURPOSE: METHODS: A double-blind, randomized, controlled crossover study was conducted on sixteen patients with T2D. Patients were randomly assigned to allulose 7 g twice daily or aspartame 0.03 g twice daily for 12 weeks. After a 2-week washout, patients were crossed over to the other sweetener for an additional 12 weeks. Oral glucose tolerance tests, laboratory measurements, and dual-energy X-ray absorptiometry were conducted before and after each phase. RESULTS: This study revealed that short-term allulose consumption exerted no significant effect on glucose homeostasis, incretin levels, or body composition but significantly increased MCP-1 levels (259 ± 101 pg/ml at baseline vs. 297 ± 108 pg/mL after 12 weeks of allulose, p = 0.002). High-density lipoprotein cholesterol (HDL-C) significantly decreased from 51 ± 13 mg/dl at baseline to 41 ± 12 mg/dL after 12 weeks of allulose, p < 0.001. CONCLUSION: Twelve weeks of allulose consumption had a neutral effect on glucose homeostasis, body composition, and incretin levels. Additionally, it decreased HDL-C levels and increased MCP-1 levels. TRIAL REGISTRATION: This trial was retrospectively registered on the Thai Clinical Trials Registry (TCTR20220516006) on December 5, 2022.
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Authors | Lukana Preechasuk, Chanoknan Luksameejaroenchai, Watip Tangjittipokin, Tada Kunavisarut |
Journal | European journal of nutrition
(Eur J Nutr)
Vol. 62
Issue 7
Pg. 2939-2948
(Oct 2023)
ISSN: 1436-6215 [Electronic] Germany |
PMID | 37432472
(Publication Type: Randomized Controlled Trial, Journal Article)
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Copyright | © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany. |
Chemical References |
- psicose
- Incretins
- Blood Glucose
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Topics |
- Humans
- Diabetes Mellitus, Type 2
(drug therapy, metabolism)
- Cross-Over Studies
- Incretins
(therapeutic use)
- Blood Glucose
(metabolism)
- Homeostasis
- Double-Blind Method
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