Abstract | AIMS: Corni Fructus (CF) and some CF-contained prescriptions are commonly used in clinical treatment of depression. This investigation aims to evaluate the main active compound of CF in antidepressant properties and its key target. METHODS: Firstly, this study established a behavioral despair model and used high-performance liquid chromatography method to evaluate the antidepressant-like effects of water extract, 20%, 50%, and 80% ethanol extracts of CF, and its main active compound. Then, this study created chronic unpredictable mild stress (CUMS) model to assess loganin's antidepressant-like properties, and its target was evaluated by quantitative real-time polymerase chain reaction, Western blot, Immunofluorescence, enzyme-linked immunosorbent assay, and tyrosine receptor kinase B (TrkB) inhibitor. RESULTS: Results showed that the different extracts of CF significantly shortened the immobility time in forced swimming and tail suspension tests. Moreover, loganin alleviated CUMS-induced depression-like behavior, promoted neurotrophy and neurogenesis, and inhibited neuroinflammation. Furthermore, K252a blocked the improvement of loganin on depression-like behavior, and eliminated the enhancement of neurotrophy and neurogenesis and the inhibition of neuroinflammation. CONCLUSION:
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Authors | Mingzhu Gong, Junming Wang, Lingling Song, Xiaohui Wu, Yanmei Wang, Bingyin Li, Yueyue Zhang, Lingyu Qin, Yaqian Duan, Bingyu Long |
Journal | CNS neuroscience & therapeutics
(CNS Neurosci Ther)
Vol. 29
Issue 12
Pg. 3842-3853
(Dec 2023)
ISSN: 1755-5949 [Electronic] England |
PMID | 37408379
(Publication Type: Journal Article)
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Copyright | © 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. |
Chemical References |
- Brain-Derived Neurotrophic Factor
- loganin
- Receptor, trkB
- Antidepressive Agents
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Topics |
- Animals
- Brain-Derived Neurotrophic Factor
(metabolism)
- Cornus
(metabolism)
- Receptor, trkB
- Neuroinflammatory Diseases
- Antidepressive Agents
(pharmacology, therapeutic use)
- Depression
(drug therapy)
- Stress, Psychological
(drug therapy)
- Hippocampus
(metabolism)
- Disease Models, Animal
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