Sex-specific responses in glucose-insulin homeostasis and lipoprotein-lipid components after high-dose supplementation with marine n-3 PUFAs in abdominal obesity: a randomized double-blind crossover study.
Abstract | Background: Objective: Methods: Results: The between-sex difference in relative change scores was significant after n-3 for total high-density lipoproteins (females/males: -11%*/-3.3%, p = 0.036; *: significant within-sex change), high-density lipoprotein particle size (+2.1%*/-0.1%, p = 0.045), and arachidonic acid (-8.3%*/-12%*, p = 0.012), and after n-6 for total (+37%*/+2.1%, p = 0.041) and small very-low-density lipoproteins (+97%*/+14%, p = 0.021), and lipoprotein (a) (-16%*/+0.1%, p = 0.028). Circulating markers of glucose- insulin homeostasis differed significantly after n-3 for glucose (females/males: -2.1%/+3.9%*, p = 0.029), insulin (-31%*/+16%, p < 0.001), insulin C-peptide (-12%*/+13%*, p = 0.001), homeostasis model assessment of insulin resistance index 2 (-12%*/+14%*, p = 0.001) and insulin sensitivity index 2 (+14%*/-12%*, p = 0.001), and quantitative insulin sensitivity check index (+4.9%*/-3.4%*, p < 0.001). Conclusion: We found sex-specific responses after high-dose n-3 (but not n-6) supplementation in circulating markers of glycemic control/ insulin sensitivity, which improved in females but worsened in males. This may partly be related to the sex differences we observed in several components of the lipoprotein- lipid profile following the n-3 intervention. Clinical trial registration: https://clinicaltrials.gov/, identifier [NCT02647333].
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Authors | Johnny Laupsa-Borge, Elise Grytten, Pavol Bohov, Bodil Bjørndal, Elin Strand, Jon Skorve, Jan Erik Nordrehaug, Rolf K Berge, Espen Rostrup, Gunnar Mellgren, Simon N Dankel, Ottar K Nygård |
Journal | Frontiers in nutrition
(Front Nutr)
Vol. 10
Pg. 1020678
( 2023)
ISSN: 2296-861X [Print] Switzerland |
PMID | 37404855
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 Laupsa-Borge, Grytten, Bohov, Bjørndal, Strand, Skorve, Nordrehaug, Berge, Rostrup, Mellgren, Dankel and Nygård. |
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