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ELAC2 is a functional prostate cancer risk allele.

Abstract
Stentenbach and colleagues have unveiled a functional role of a human germline mutation found in the ribonuclease (RNase) Z enzyme, ELAC2, in prostate cancer. Here, we discuss the importance of these findings in enhancing our understanding of how risk variants enable prostate cancer progression and the post-transcriptional mechanisms underlying oncogenesis.
AuthorsSteven Blinka, Rashmi Mishra, Andrew C Hsieh
JournalTrends in molecular medicine (Trends Mol Med) Vol. 29 Issue 8 Pg. 586-588 (Aug 2023) ISSN: 1471-499X [Electronic] England
PMID37353407 (Publication Type: Journal Article)
CopyrightCopyright © 2023 Elsevier Ltd. All rights reserved.
Chemical References
  • ELAC2 protein, human
  • Neoplasm Proteins
Topics
  • Male
  • Humans
  • Alleles
  • Prostatic Neoplasms (genetics)
  • Genetic Predisposition to Disease
  • Neoplasm Proteins (genetics)

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