Abstract | OBJECTIVES: The aim of this study was to describe the bacterial profile of middle ear fluid from spontaneous perforation of the tympanic membrane (SPTM) prior to widespread utilization of third- generation pneumococcal conjugate vaccines (PCVs). PATIENTS AND METHODS: From October 2015 to January 2023, children with SPTM were prospectively enrolled by pediatricians. RESULTS: Among the 852 children with SPTM, 73.2% were less than 3 years old; more frequently than older children, they were and suffering from complex acute otitis media (AOM) (27.9%) and conjunctivitis (13.1%). In children under 3 years of age, NT Haemophilus influenzae (49.7%) was the main otopathogen isolated, particularly in those with complex AOM (57.1%). In children over 3 years of age, Group A Streptococcus accounted for 57%. In pneumococcal cases (25.1%), serotype 3 was the main serotype isolated (16.2%), followed by 23B (15.2%). CONCLUSION: Our data from 2015 to 2023 represent a robust baseline preceding the widespread utilization of next-generation PCVs.
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Authors | Corinne Levy, Emmanuelle Varon, Philippe Bidet, Stéphane Béchet, Christophe Batard, Alain Wollner, Franck Thollot, Stéphane Bonacorsi, Robert Cohen |
Journal | Infectious diseases now
(Infect Dis Now)
Vol. 53
Issue 6
Pg. 104738
(Sep 2023)
ISSN: 2666-9919 [Electronic] France |
PMID | 37331698
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 The Author(s). Published by Elsevier Masson SAS.. All rights reserved. |
Chemical References |
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Topics |
- Humans
- Child
- Child, Preschool
- Adolescent
- Vaccines, Conjugate
- Prospective Studies
- Otitis Media
(epidemiology, prevention & control, microbiology)
- Streptococcus pneumoniae
- Bacteria
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