Abstract |
We evaluated relative vaccine effectiveness (rVE) of 4- vs. 3-dose mRNA-1273 against SARS-CoV-2 infection, and COVID-19 hospitalization and death in immunocompetent adults aged ≥50 years at Kaiser Permanente Southern California. We included 178,492 individuals who received a fourth dose of mRNA-1273, and 178,492 randomly selected 3-dose recipients who were matched to 4-dose recipients by age, sex, race/ethnicity, and third dose date. Adjusted 4- vs. 3-dose rVE against SARS-CoV-2 infection, COVID-19 hospitalization, and COVID-19 hospitalization death were 25.9 % (23.5 %, 28.2 %), 67.3 % (58.7 %, 74.1 %), and 72.5 % (-35.9 %, 95.2 %), respectively. Adjusted rVE against SARS-CoV-2 infection ranged between 19.8 % and 39.1 % across subgroups. Adjusted rVE against SARS-CoV-2 infection and COVID-19 hospitalization decreased 2-4 months after the fourth dose. Four mRNA-1273 doses provided significant protection against COVID-19 outcomes compared with 3 doses, consistent in various subgroups of demographic and clinical characteristics, although rVE varied and waned over time.
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Authors | Jennifer H Ku, Lina S Sy, Lei Qian, Bradley K Ackerson, Yi Luo, Julia E Tubert, Gina S Lee, Ana Florea, Katia J Bruxvoort, Fagen Xie, Sijia Qiu, Scott Chavers, Carla A Talarico, Hung Fu Tseng |
Journal | Vaccine
(Vaccine)
Vol. 41
Issue 29
Pg. 4212-4219
(06 29 2023)
ISSN: 1873-2518 [Electronic] Netherlands |
PMID | 37301708
(Publication Type: Observational Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved. |
Chemical References |
- 2019-nCoV Vaccine mRNA-1273
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Topics |
- Humans
- United States
(epidemiology)
- Aged
- 2019-nCoV Vaccine mRNA-1273
- COVID-19
(prevention & control)
- SARS-CoV-2
- Cohort Studies
- Ethnicity
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