A case of canine visceral leishmaniasis of unknown origin in Curitiba (state of Paraná, Brazil) treated successfully with miltefosine.

Abstract

There are no records of autochthonous cases of canine visceral leishmaniasis in the city of Curitiba, Paraná state, Brazil. In 2020, a male French bulldog (CW01), approximately 2 years old was taken by its owners to a private veterinarian clinic. The suspicion of CVL was confirmed by means of a serology test (ELISA/IFAT reagent), rapid chromatographic immunoassay (DPP®) (ELISA - Biomanguinhos®), parasitological culture and quantitative polymerase chain reaction (qPCR). The animal routinely frequented parks in Curitiba and was taken on several trips to the municipalities of Bombinhas and Balneário Camboriú (Santa Catarina) and to Matinhos (Paraná) where CVL had not previously been reported. Treatment was initiated orally with Milteforan™ which resulted in a significant reduction in the parasitic load. The suspicion of autochthony was investigated through entomological research. A total of 10 traps were installed, one at the animal's home, seven in adjacent city blocks and two in a forest edge. No sandflies were trapped in the dog's home and adjacent houses. The traps in the forest edge caught one Migonemyia migonei female and five Brumptomyia spp. females. This case serves as a warning of the possible introduction of CVL in the city of Curitiba.

• Authors: Gustavo Gonçalves, Monique Paiva Campos, Thais Cristina Tirado, Dayane Domingos Negrão, Gabriela Mayoral Pedroso da Silva, Ana Paula Coninck Mafra Poleto, Tatianna Paula Hartin, Juliana Batista Andrade Silva, Marilia de Melo Santos de Castilhos, Fabiano Borges Figueiredo
• Journal: Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria (Rev Bras Parasitol Vet) Vol. 32 Issue 2 Pg. e001123 ( 2023) ISSN: 1984-2961 [Electronic] Brazil
• PMID: 37194787 (Publication Type: Case Reports, Journal Article)

Chemical References

• miltefosine
• Phosphorylcholine

Topics

• Animals
• Dogs
• Female
• Male
• Brazil
• Dog Diseases (diagnosis, drug therapy, parasitology)
• Leishmaniasis, Visceral (diagnosis, drug therapy, veterinary)
• Phosphorylcholine (therapeutic use)