Polyamidoamine dendrimer decorated graphene oxide as a pH-sensitive nanocarrier for the delivery of hydrophobic anticancer drug quercetin: a remedy for breast cancer.

Abstract

OBJECTIVES:

The aim of this study was to investigate the potential of poly(amido amine) (PAMAM) dendrimer decorated graphene oxide (GO) based nanocarrier for targeted delivery of a hydrophobic anticancer drug, quercetin (QSR).

METHODS:

GO-PAMAM was successfully synthesized by covalent bonding between GO and NH2-terminated PAMAM dendrimer (zero generation). To investigate drug loading performance, QSR was loaded on the surface of GO as well as GO-PAMAM. Further, the release behaviour of QSR-loaded GO-PAMAM was studied. Finally, an in-vitro sulforhodamine B assay was performed in HEK 293T epithelial cells and MDA MB 231 breast cancer cells.

KEY FINDINGS:

It was observed that GO-PAMAM shows higher QSR loading capacity compared to GO. Also, synthesized nanocarrier exhibits controlled as well as pH-responsive release of QSR and the amount of QSR released at pH 4 was approximately two times higher than the release at pH 7.4. Furthermore, GO-PAMAM was found to be biocompatible for HEK 293T cells, and a high cytotoxic effect was observed for QSR-loaded GO-PAMAM on MDA MB 231 cells.

CONCLUSIONS:

The present investigation highlights the potential application of synthesized hybrid materials as a nanocarrier with excellent loading and controlled releasing efficiency for the delivery of the hydrophobic anticancer drug.

• Authors: Monika Matiyani, Anita Rana, Mintu Pal, Sumit Dokwal, Nanda Gopal Sahoo
• Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 75 Issue 6 Pg. 859-872 (Jun 05 2023) ISSN: 2042-7158 [Electronic] England
• PMID: 37134308 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2023. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• Dendrimers
• Poly(amidoamine)
• graphene oxide
• Quercetin
• Antineoplastic Agents
• Drug Carriers

Topics

• Humans
• Female
• Dendrimers (chemistry, pharmacology)
• Breast Neoplasms (drug therapy)
• Quercetin (pharmacology)
• Antineoplastic Agents (pharmacology, chemistry)
• Hydrogen-Ion Concentration
• Drug Carriers (chemistry)
• Drug Delivery Systems