Abstract | BACKGROUND: METHODS: In this prospective, non-randomized, longitudinal cohort study, 23 and 22 subjects were recruited and underwent LASEK and FS- LASIK, respectively. After conducting an intact ophthalmic examination and collecting relevant surgical data, all subjects were examined for VIP concentration in their tears using ELISAs, tear-film breakup time, ocular staining and ocular surface disease index questionnaire before surgery and 1 day, 1 week, and 1 month post-surgery. RESULTS: Tear VIP concentration increased significantly after both LASEK and FS- LASIK, with the highest concentration observed 1 week post-surgery (P ≤ 0.05). Tear VIP concentration correlated negatively with corneal ablation depth (AD). The extent of dry eyes was related to the operation method employed and postoperative recovery period. In FS- LASIK and LASEK subjects, dry eyes were mainly affected by the basic ocular surface status before surgery, and VIP concentration. Furthermore, in LASEK subjects, dry eyes were negatively correlated with AD. CONCLUSION: VIP was stimulated and mobilized as an emergency protection post- refractive surgery and a trauma model affected by AD. It can indirectly indicate the inevitable relationship between postoperative dry eye and nerve injury. Elevated post-surgery tear VIP relieves dry eye symptoms, showing its neuroimmune role in regulating adverse injury stimulation. The present study provides a solution to the pathogenesis of postoperative dry eyes. TRIAL REGISTRATION: The trial registration number: 2021JS22. Date of registration: 10 May 2021.
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Authors | Yang Kang, Qi Hu, Xue Li, Zidan Guo, Qiong Wu, Hong Zhang |
Journal | BMC ophthalmology
(BMC Ophthalmol)
Vol. 23
Issue 1
Pg. 167
(Apr 20 2023)
ISSN: 1471-2415 [Electronic] England |
PMID | 37081425
(Publication Type: Clinical Trial, Journal Article)
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Copyright | © 2023. The Author(s). |
Chemical References |
- Vasoactive Intestinal Peptide
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Topics |
- Humans
- Cornea
(surgery, physiology)
- Dry Eye Syndromes
(etiology)
- Keratomileusis, Laser In Situ
(adverse effects, methods)
- Lacerations
- Lasers, Excimer
(therapeutic use)
- Longitudinal Studies
- Myopia
(surgery)
- Prospective Studies
- Tears
- Vasoactive Intestinal Peptide
- Cohort Studies
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