This study aimed to evaluate the non-invasive and subjective symptoms associated with Lehfilcon A water gradient
silicone hydrogel contact lenses with bacterial and
lipid resistance technology. A prospective, longitudinal, single-centre, self-controlled study was conducted among
silicone hydrogel contact lens wearers. Non-invasive analysis of the pre-lens tear film was performed using the Integrated Clinical Platform (ICP) Ocular Surface Analyzer (OSA), and the meibomian glands were evaluated with the Cobra® HD infrared meibographer. After 30 days of
contact lens wear, the subjects were re-evaluated to determine the changes in conjunctival redness, subjective
dry eye disease, tear meniscus height,
lipid pattern, and non-invasive break-up time. Results showed that the
lipid layer thickness decreased significantly from 2.05 ± 1.53 to 0.92 ± 1.09 Guillon patterns, and the tear meniscus height decreased from 0.21 ± 0.04 to 0.14 ± 0.03. The mean pre-lens non-invasive break-up time (NIBUT) significantly increased from 15.19 ± 9.54 to 25.31 ± 15.81 s. The standard Patient Evaluation of
Eye Disease (SPEED) score also decreased from 7.39 ± 4.39 to 5.53 ± 4.83. The results suggest that Lehfilcon A significantly reduced
lipid and aqueous tear film volume but improved break-up time and subjective
dry eye symptoms.