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Celastrol activates mitochondrial autophagy through Nur77-TRAF2-p62/SQSTM1 pathway in the treatment of experimental colitis.

AuthorsDandan Chen, Lu Ye, Yongpan Liu, Jingxia Yu, Siyi Ni, Yi Chen, Jihong Zhong
JournalMinerva pediatrics (Minerva Pediatr (Torino)) Vol. 75 Issue 5 Pg. 760-762 (10 2023) ISSN: 2724-5780 [Electronic] Italy
PMID37021620 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • celastrol
  • Nr4a1 protein, mouse
  • Sequestosome-1 Protein
  • Sqstm1 protein, mouse
  • TNF Receptor-Associated Factor 2
  • TRAF2 protein, mouse
Topics
  • Humans
  • Autophagy (drug effects)
  • Colitis (drug therapy, genetics, metabolism)
  • Mitochondria (drug effects, metabolism)
  • Sequestosome-1 Protein (metabolism)
  • TNF Receptor-Associated Factor 2 (metabolism)

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