Dramatically Improved Severe Pulmonary Arterial Hypertension Caused by Qing-Dai (Chinese Herbal Drug) for Ulcerative Colitis.

Abstract

Pulmonary arterial hypertension (PAH) is a rare and fatal disease for which some causative drugs have been developed. Qing-Dai is a Chinese herbal drug that is sometimes used as a specific treatment for ulcerative colitis in Asia, including Japan. Here, we report a case of severe Qing-Dai-induced PAH. A 19-year-old woman who has been taking Qing-Dai for 8 months was admitted for exertional dyspnea. Her mean pulmonary artery pressure dramatically improved from 72 to 18 mmHg with Qing-Dai discontinuation and PAH-specific therapy. After 6 years of onset, she had not relapsed with PAH with PAH-specific therapy.

• Authors: Kana Kubota, Yasushi Imai, Takafumi Okuyama, Yusuke Ishiyama, Shuichi Ueno, Kazuomi Kario
• Journal: International heart journal (Int Heart J) Vol. 64 Issue 2 Pg. 316-320 ( 2023) ISSN: 1349-3299 [Electronic] Japan
• PMID: 37005323 (Publication Type: Case Reports, Journal Article)

Chemical References

• Drugs, Chinese Herbal

Topics

• Humans
• Female
• Young Adult
• Adult
• Colitis, Ulcerative (drug therapy)
• Drugs, Chinese Herbal (adverse effects)
• Pulmonary Arterial Hypertension (drug therapy, etiology)
• Hypertension, Pulmonary (drug therapy, chemically induced)
• Arteries