Prediction of Malignant Thyroid Nodules Using 18 F-FDG PET/CT-Based Radiomics Features in Thyroid Incidentalomas.

Abstract

OBJECTIVE:

The purpose of the current study was to evaluate the diagnostic performances of 18 F-FDG PET/CT-based radiomics features for prediction of malignant thyroid nodules (TNs) in thyroid incidentaloma (TI).

METHODS:

PubMed, Cochrane database, and EMBASE database, from the earliest available date of indexing through December 31, 2022, were searched for studies evaluating diagnostic performance of 18 F-FDG PET/CT-based radiomics features for prediction of malignant TNs in TI. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LRs; positive and negative LRs), and estimated pooled area under the curve.

RESULTS:

Across 5 studies (518 patients), the pooled sensitivity of 18 F-FDG PET/CT was 0.77 (95% confidence interval [CI], 0.67-0.84), and a pooled specificity was 0.67. Likelihood ratio syntheses gave an overall positive LR of 2.3 (95% CI, 1.5-3.6) and negative LR of 0.35 (95% CI, 0.26-0.47). The pooled diagnostic odds ratio was 7 (95% CI, 4-12). The pooled area under the curve of fixed effects was 0.763 (95% CI, 0.736-0.791), and that of random effects was 0.763 (95% CI, 0.721-0.805).

CONCLUSION:

18 F-FDG PET/CT-based radiomics features showed a good diagnostic performance for prediction of malignant TNs in TI.

• Authors: Woo Seog Ko, Seong-Jang Kim
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 48 Issue 6 Pg. 497-504 (Jun 01 2023) ISSN: 1536-0229 [Electronic] United States
• PMID: 37001129 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Fluorodeoxyglucose F18
• Radiopharmaceuticals

Topics

• Humans
• Positron Emission Tomography Computed Tomography
• Fluorodeoxyglucose F18
• Radiopharmaceuticals
• Thyroid Nodule (diagnostic imaging)
• Sensitivity and Specificity