Health Technology Assessment of Different Glucosamine Formulations and Preparations Currently Marketed in Thailand.

Abstract

OBJECTIVE:

The aim of this study was to evaluate the cost-effectiveness of different glucosamine formulations and preparations used for the management of osteoarthritis in Thailand compared with placebo.

METHODS:

We used a validated model to simulate the individual patient Utility score from aggregated data available from 10 different clinical trials. We then used the Utility score to calculate the quality-adjusted life year (QALY) over 3 and 6 months treatment period. We used the public costs of glucosamine products available in Thailand in 2019 to calculate the incremental cost-effectiveness ratio. We separated the analyses for prescription-grade crystalline glucosamine sulfate (pCGS) and other formulations of glucosamine. A cost-effectiveness cut-off of 3.260 USD/QALY was considered.

RESULTS:

Irrespective of the glucosamine preparation (tablet or powder/capsule), the data show that pCGS is cost-effective compared with placebo over a 3 and 6 months. However, the other glucosamine formulations (e.g., glucosamine hydrochloride) never reached the breakeven point at any time.

CONCLUSIONS:

Our data show that pCGS is cost-effective for the management of osteoarthritis in the Thai context while other glucosamine formulations are not.

• Authors: Olivier Bruyère, Johann Detilleux, Jean-Yves Reginster
• Journal: Medicines (Basel, Switzerland) (Medicines (Basel)) Vol. 10 Issue 3 (Mar 08 2023) ISSN: 2305-6320 [Print] Switzerland
• PMID: 36976312 (Publication Type: Journal Article)