The Relationship Between Expression of EpCAM Cancer Stem Cell Marker with Histopathological Grading, Lymphovascular Invasion, and Metastases in Colorectal Adenocarcinoma.

Abstract

OBJECTIVE:

The aim of this study was to analyze the expression of EpCAM in the colorectal adenocarcinoma.

MATERIAL AND METHODS:

This study used a cross-sectional design. One hundred and thirteen paraffin embedded block of Colorectal Adenocarcinoma were assessed using anti-EpCAM/Epithelial Specific Antigen (Ber-EP4) mouse monoclonal antibody and their expression were performed using Olympus CX-43 light microscope. The relationship between EpCAM expression with histopathological grade of colorectal adenocarcinoma, lymphovascular invasion and metastases ability were statistically analyzed by Chi-Square tests and presented in tables using SPSS 18.

RESULTS:

From 113 samples, in samples with lymphovascular invasion there were 37 samples (32.7%) with strong expression, while those with weak expression were 19 samples (16.8%). There were 39 samples with metastases and strong expression of EpCAM (34.5%), while 21 samples with weak expression (18.6%). There was a significant relationship between the expression of cancer stem cell marker EpCAM with lymphovascular invasion and colorectal adenocarcinoma metastases (p = 0.002), but there was no significant relationship with histopathological grade (p = 0.574).

CONCLUSION:

The EpCAM expression can be used as a prognostic factor, and can be considered as a predictive or an option for target therapy in colorectal adenocarcinoma.

• Authors: Lenda Olivia Gaghana, Upik Miskad, Muhammad Husni Cangara, Andi Alfian Zainuddin, Mardiati Mardiati, Gunawan Arsyadi, Syarifuddin Wahid
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 24 Issue 3 Pg. 929-934 (Mar 01 2023) ISSN: 2476-762X [Electronic] Thailand
• PMID: 36974547 (Publication Type: Journal Article)

Chemical References

• Epithelial Cell Adhesion Molecule

Topics

• Animals
• Mice
• Epithelial Cell Adhesion Molecule (metabolism)
• Prognosis
• Cross-Sectional Studies
• Adenocarcinoma (pathology)
• Colorectal Neoplasms (pathology)
• Neoplastic Stem Cells (metabolism)